Klucel™ LF Pharma, SDS · TDS*. Klucel™ M CS, Klucel™ M CS has excellent film-forming properties and thickens non-aqueous systems and provide lubricious. Klucel hydroxypropylcellulose (HPC) provides a remarkable set of physical properties for tablet binding, modified release, and film coating. This unique polymer. Klucel hydroxypropylcellulose (HPC) is a nonionic water-soluble cellulose ether with Klucel HPC is soluble in many polar organic solvents and in water below.

Author: Samugor Mautaxe
Country: Estonia
Language: English (Spanish)
Genre: Science
Published (Last): 4 January 2010
Pages: 495
PDF File Size: 7.91 Mb
ePub File Size: 5.55 Mb
ISBN: 900-3-90800-163-2
Downloads: 30454
Price: Free* [*Free Regsitration Required]
Uploader: Dourisar

Import Data and Price of klucel lf pharm | Zauba

Chem Pharm Bull Tokyo ; 41 2: Drug-polymer solubility and miscibility: In Vitro Randomized Controlled Trial. In vitro release klhcel were performed on tablets stored at different stability conditions. Samples were collected at every 0. Extrudates were milled and compressed with the addition of Kluucel as a direct compression vehicle, and AcDisol aided disintegration.

True density measurements of the tabletting blends were performed using a Micromeritics helium pycnometer AccuPyc IICommunications Dr. Ketoprofen KPR is a non-steroidal anti-inflammatory drug commonly used in treatment of pain and inflammation.

Received Apr 25; Accepted Jul kluceo The difference could be attributed to absorption of moisture onto tablets that affected the disintegration time and hence a slower release at high humidity conditions.

Physical mechanical and tablet formation properties of hydroxypropylcellulose: Characterization and solubility study of solid dispersions of flunarizine and polyvinylpyrrolidone. A similar decrease in release has been observed in extruded matrices by Crowley et al.


Search Import Export Data of India

This densification leads to a delayed disintegration and also decreased surface area. Ashland obtains all its offerings from renewable, natural raw materials, klcel in Good Manufacturing Practices cGMP -compliant facilities around the world.

The extent of deformation as measured by the percentage change in diameter of the tablet at failure breaking was higher for extruded tablets Fig.

BoxKeokuk, IA Pharmacokinetics of ketoprofen following single oral, intramuscular and rectal doses and after repeated mlucel administration.

Being nonionic, pH-independent release can be achieved from matrices manufactured from these polymers. Tensile strength was ,f from hardness values utilizing the following equation.

Klucel® Hydroxypropylcellulose LF by Ashland – Food, Beverage & Nutrition

Extrudates were evaluated for any recrystallization that might have occurred at the end of storage time points. However, UL assumes no responsibility or liability for the accuracy of the information contained on this website and strongly encourages that upon final product or material selection information is validated with the manufacturer.

Tabletability is represented by a plot of tensile strength versus compaction pressure, Compactibility by a plot of tensile strength versus porosity, and Compressibility by a plot of porosity versus compaction pressure Formulations with mannitol as a pore former, H2 and H4, released Release profiles were plotted for percent release to time. As per Higuchi matrix model, release from a matrix occurs by dissolution and diffusion of one component through the other Leuner C, Dressman J.

DSC studies have been employed to characterize miscibility of kkucel systems extensively Properties of hot-melt extruded theophylline tablets containing poly vinyl acetate Drug Dev Ind Pharm.



Stability of such a system can be attributed to increased solid state solubility and hydrogen bond forming tendency of HPC Addition of mannitol resulted in a decrease in hardness values.

An increase in drug loading resulted in a decreased release and a drop in bioavailability for ritonavir-based solid dispersions.

Carrier-mediated or drug-related phase conversion or precipitation can occur in super saturated conditions in these formulations. The dissolution profiles klucfl presented in Fig. Formulation studies of a poorly water-soluble drug in solid dispersions to improve bioavailability. Addition of mannitol MNT further enhanced the release by forming micro-pores and increasing the porosity of the extrudates.

,lucel Its ingredients are globally recognized for performance, quality, and consistency. Pharmaceutical applications of hot-melt extrusion: The data were analyzed utilizing TA Universal Analysis software and glass transition Tg temperature calculated by taking the midpoint of tangents drawn. Improved dissolution and pharmacokinetic behavior of cyclosporine A using high-energy amorphous solid dispersion approach.

Ashland is a developer and manufacturer of stabilizers and gums used in the Food, Beverage, and Nutrition klhcel. The hot-stage microscope confirmed the formation of a miscible amorphous system of KPR—EF mixtures Compressibility, Compactibility, and Tabletability profiles as described by Tye et al.

Previous post: