INTRATUMOR HETEROGENEITY AND BRANCHED EVOLUTION REVEALED BY MULTIREGION SEQUENCING PDF

INTRATUMOR HETEROGENEITY AND BRANCHED EVOLUTION REVEALED BY MULTIREGION SEQUENCING PDF

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing. / Gerlinger, Marco; Rowan, Andrew J.; Horswell, Stuart; Larkin, James;. Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion . intratumor heterogeneity, we performed exome sequencing, chromosome. Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing N Engl J Med ;–92Re: Single-cell Exome Sequencing Reveals.

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Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.

Intratumor heterogeneity was observed for a mutation within an autoinhibitory domain of the mammalian target of rapamycin mTOR kinase, correlating with S6 and 4EBP phosphorylation in vivo and constitutive activation of mTOR kinase activity in vitro.

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Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. – FPrime

See N Engl J Med. A summary of the content will be automatically included. Allelic composition and ploidy profiling analysis revealed extensive intratumor heterogeneity, with 26 of 30 tumor samples from four tumors harboring divergent allelic-imbalance profiles and with ploidy heterogeneity in two of four tumors. Mutational intratumor heterogeneity was seen for multiple tumor-suppressor genes converging on evolutiom of function; SETD2, PTEN, and KDM5C underwent multiple distinct and spatially revealled inactivating mutations within a single tumor, suggesting convergent phenotypic evolution.

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An analysis of natural T cell responses to predicted tumor neoepitopes [Front Immunol, 8,] doi: Find all citations in this journal default. Recommend to your librarian. CitePeer Related Articles http: You have a close personal relationship e. Personalized medicine and tumour heterogeneity. Intratumor heterogeneity was observed for a mutation within an autoinhibitory domain of the mammalian target of rapamycin mTOR kinase, correlating with S6 and 4EBP phosphorylation in vivo and constitutive activation of mTOR kinase activity in vitro.

N Engl J Med. Accordingly you may only post Material that you have the right sequecning do so. Intratumor heterogeneity can lead to underestimation of the tumor genomics landscape portrayed from single tumor-biopsy samples and may present major challenges to personalized-medicine and biomarker development.

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We characterized the consequences of intratumor heterogeneity using immunohistochemical analysis, mutation functional analysis, and profiling of messenger RNA expression.

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Gene-expression signatures of good and poor prognosis were detected in different regions of the same tumor. Andrew ; Swanton, Charles. Recommendations Abstract Comments You have reached your article limit.

Examples of ‘Financial Competing Interests’ You expect to receive, or in the past 4 years have received, any of the following from any commercial organization that may gain financially from your submission: Intratumor heterogeneity may foster tumor evolution and adaptation and hinder personalized-medicine strategies that depend on results from single tumor-biopsy samples.

The New England Journal of Medicine. Allelic composition and ploidy profiling analysis revealed extensive intratumor heterogeneity, with 26 of 30 tumor samples from four tumors harboring divergent allelic-imbalance profiles and with ploidy heterogeneity in two of four tumors.