Rotate the site of injection to avoid irritation or sterile abscess formation with repeat administration. Intramuscular Depot injection (fluphenazine decanoate or . PACKAGE LEAFLET: INFORMATION FOR THE USER. Modecate® 25mg/ml Injection fluphenazine decanoate. Is this leaflet hard to see or read? Phone . ADMINISTRATION). Fluphenazine decanoate is not indicated for the management of severely agitated psychotic patients or psychoneurotic.
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Oedema has been reported with phenothiazine medication. Phenothiazines are known to cause photosensitivity reactions but this has decanpate been reported for fluphenazine. In addition, promethazine is associated with QT prolongation and fluphenazine is associated with a possible risk of QT prolongation. Reporting of suspected adverse reactions.
ECG changes with prolongation of the QT interval and T-Wave changes have been reported commonly in patients treated with moderate to high dosage; they have been reported to precede serious arrhythmias, including ventricular tachycardia and fibrillation, which have also occurred after overdosage. Minor Since degarelix can cause QT prolongation, degarelix should be used cautiously, if at all, with other drugs that are associated with QT prolongation like fluphenazine.
Lapatinib should be flu;henazine with caution to patients who have fluphenazime may develop prolongation of QTc such as patients taking anti-arrhythmic medicines or other medicinal products that lead to QT prolongation.
Whether antipsychotics differ in their potential to cause tardive dyskinesia is unknown. Some hyperprolactinemic women with normal menstruation isnert have an increased number of anovulatory cycles, which may result in subfertility. Emtricitabine; Rilpivirine; Tenofovir alafenamide: There have been case reports of QT prolongation and TdP with the use of azithromycin in postmarketing reports. Minor Because fluphenazine and SSRIs including escitalopram are associated with a possible risk of QT prolongation and torsade de pointes TdPcombination therapy should be used cautiously and with close monitoring.
Drugs with a possible risk for QT prolongation that should be used cautiously with droperidol include decanowte. Consider reducing the dosage of phenothiazine and titrating to clinical effect. According to the manufacturer, since iloperidone may prolong the Pacmage interval, it should not be used with other agents also known to have this effect, such as fluphenazine. At high doses, loperamide has been associated with serious cardiac toxicities, including syncope, ventricular tachycardia, QT prolongation, torsade de pointes TdPand cardiac arrest.
Neuroleptic malignant syndrome NMS has been observed occasionally during concurrent use of lithium and either atypical or conventional antipsychotics. We do not record any personal information entered above. Patients who have suffered a relapse following cessation of depot fluphenazine therapy may be restarted on the same dose, although the frequency of injections may need to be increased in the early weeks of treatment until satisfactory control is obtained.
Other drugs that may also cause drowsiness, such as phenothiazines, should be used with caution. fluphennazine
Lofexidine may potentiate the effects of CNS depressants, including fluphenazine. Psychotic patients on large doses of phenothiazines who are undergoing surgery should be watched carefully for hypotension.
Fluphenazine decanoate and fluphenazine enanthate are depot injection formulations should not be utilized in patients with hepatic impairment. Atomoxetine and fluphenazine are considered drugs with a possible risk of torsade de pointes TdP. Moderate Phenothiazines can potentiate the CNS depressant action of other drugs such as opiate agonists.
Packag, like other antipsychotics, has the potential to impair judgment, thinking, or motor skills. In addition, in the absence of relevant data and as a precaution, drugs that cause hyperprolactinemia e.
Modecate Injection 25mg/ml
Moderate Additive effects may be seen when phenothiazines are used concomitantly with other drugs with antimuscarinic activity, such as dexchlorpheniramine, a sedating H1-blocker. Minor Due to the potential for QT prolongation and torsade de pointes TdPcaution is advised when administering fluphenazine with mefloquine. Acute dystonic reactions occur infrequently, as a rule within the fluphenazzine hours, although delayed reactions may occur.
CNS depressants can potentiate the effects of cannabidiol. Administer using a calibrated measuring device.
Moderate Antipsychotics, such as phenothiazines, and dexmethylphenidate may interact pharmacodynamically to diminish the therapeutic effects of either agent through opposing effects on dopamine. Phenothiazines are excreted fluphenazinw breast milk; drowsiness, lethargy, and developmental delays have been reported in the nursing infant.
A dose reduction may be required if combination therapy is necessary.