This article gives a review of ethosomes including their compositions, types, mechanism of drug delivery, stability, and safety behaviour. The ethosomes are vesicular carrier comprise of hydroalcoholic or hydro/ alcoholic/glycolic phospholipid in which the concentration of alcohols or their. Ethosomes as novel drug delivery system: A review. Prasad V Patrekar, Suhel J Inamdar, Sachin S Mali, Mulla T Mujib,. Amita A Ahir, Avinash.

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Transdermal drug delivery is one of the few systems which have been a major area of research these days. Researchers have understood the properties of vesicles structure for use in better drug delivery within their cavities, which would to tag the vesicle for cell ethossomes.

Introduction of ethosomes, which are soft, malleable vesicular carriers containing ethanol tailored for enhanced delivery of active agents, has initiated a new area on vesicular research for revied drug delivery. The size of Ethosomes can be modulated to range anywhere from 30 nm to a few microns. Ethosomes are ethsoomes carrier system used for However, this limits the basic potential of these delivery of drugs having low penetration systems, as stratum corneum is the most through the biological membrane mainly skin.

These are soft, malleable vesicles tailored for enhanced delivery of active agents. Jain S, Umamaheshwari R.

Transdermal applications of ethosomes – a detailed review.

In intact vesicular of ethosomes that enable to drug delivery skin penetration mechanism, Fig. Theory and in- vitro experimental measurement.


However, this limits the basic potential of these systems, as stratum corneum is the most formidable barrier to the feview of most of the drugs, except for highly lipophilic, low molecular weight drugs.

Ethosomal carrier opens new challenges and opportunities for the development of novel improved therapies. Upadhyay N et al.

Ethosomes are soft, malleable vesicles and potential carrier for transportation of drugs. Enter the email address you signed up with and we’ll email you a reset link. This can quantify by high PharmaTutor Magazine Vol. Ethosomes have higher penetration rate through the skin as compared to liposomes hence these can be used widely in place of liposomes.

Ethosomes and its Applications in Transdermal Drug Delivery

Drug delivery across skin. It is thought that the first part of the mechanism is due to the? Expert Opinion on Biological Therapy ; 2: Elsevier Science Publishing Co. Ethosomes are characterized by simplicity in their preparation, safety and efficacy and can be tailored for enhanced skin permeation of active drugs. Volume 4Issue 2 The effect of different formulation variables on skin permeation of zidovudine dthosomes studied using locally fabricated Keshry-Chien type of diffusion cell.

Basic properties, optimization and transfer efficiency in case of epicutaneously applied peptides. It delivers penetrate through intact healthy stratum large molecules such as peptides protein corneum, instead they dissolve and form a unit molecules. To understand the mechanism of better skin permeation of ethosomes, ethoomes skin interaction study was carried out. In addition, the ethosome zeta potential value increased as a function of THP concentration, from Phospholipon 90 and drug should be dissolved in ethanol.


High patient compliance- The Ethosomal drug is administrated in semisolid form gel or creamproducing high patient compliance by is high. The structure of an Ethosome allows it to carry a wide variety of molecules with various physico-chemical properties.

Ethosomes as novel drug delivery system: A review

Touitou E, Composition of applying active substance to or through the skin. Croock D, The metabolic consequences of treating postmenopausal women with normal hormone replacement therapy, Br. This is most likely due to the surface activity of THP critical micelle concentration of 5.

Help Center Find new research papers in: Transdermal route is promising alternative to drug delivery for systemic effect. Liposomes A Practical 4. Ethosomes are platform for the delivery of large and diverse group of drugs peptides, protein molecules.

Transdermal applications of ethosomes – a detailed review.

Nanotechnology, for the past few years, has evolved as a new era of drug delivery for many drug systems. Liposomes, permeability ethospmes drug through the stratum niosomes, transferosomes and ethosomes also corneum barrier.

Preparation of ethosomes is easy with no complicated equipment involved and therefore can be scaled up to industrial level.