Correspondence from The New England Journal of Medicine — Cellulitis. To the Editor: In their article on the Prophylactic Antibiotics for the Treatment of Cellulitis at Home I (PATCH I) trial, Thomas et al. (May 2 issue)1 report that the. In a recent retrospective study of patients who were hospitalized with presumed cellulitis, dermatologists concluded that roughly 30% of.

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Leg Ulcers and recurrent cellulitis –

Cellulitis of the leg is a common bacterial infection of the skin and underlying tissue. Are they suitable for compression? N Engl J Med. Prophalactic antibiotics for the prevention of cellulitis erysipelas of the leg: We compared prophylactic low-dose penicillin with placebo for the prevention of recurrent cellulitis.

In patients with recurrent cellulitis of the leg, penicillin was effective in preventing subsequent attacks during prophylaxis, but the protective effect diminished progressively once drug therapy was stopped. Antibiotics do not improve healing unless active infection. We conducted a double-blind, randomized, controlled trial involving patients with two or more episodes of cellulitis of the leg who were recruited in 28 hospitals in the United Kingdom and Ireland.


Is it chronic changes of venous stasis and chronic ulceration? Bilateral cellulitis is uncommon. Participants were followed for up to 3 years.

Penecillin to prevent leg cellulitis NEJM ; Many antibiotics increase the risk of bleeding with anticoagulants. The median time to a first recurrence of cellulitis was days in the penicillin group and days in the placebo group.

A total of patients were recruited. Baseline characteristics were similar in the two groups. Statins can interact with some antibiotics and increase the risk of rhabdomyolysis. Please refer to our Drug Interactions Table for further information. Leg Ulcers and recurrent cellulitis.

Randomization was performed according to a computer-generated code, and study medications penicillin [ mg twice a day] or placebo for 12 months were dispensed by a central pharmacy. Amiodarone and drugs which prolong the QT interval can interact with many antibiotics.

Penicillin to prevent recurrent leg cellulitis.

Cellulifis tinea pedis or candida infection with topical terbenifine or miconazole respectively. Because the risk of recurrence was not constant over the 3-year period, the primary hypothesis was tested during prophylaxis only.


The primary outcome was the time to a first recurrence. Skip to main content.

Penicillin to prevent recurrent leg cellulitis.

Comments from Expert Advisory Committee Antibiotics do not improve healing unless active infection. Refer for specialist opinion if severe infection Is it cellulitis? Comment in N Engl J Med. cellulitos

Doses are hejm and for adults unless otherwise stated. Overall, participants in the penicillin group had fewer repeat episodes than those in the placebo group vs.

Review antibiotics after culture results. Colonisation is likely in leg ulcers.