The Finnish Medicines Agency (Fimea) compiles, produces, evaluates and distributes evidence-based impartial information on pharmaceuticals to the general. biological preparatory medicine that improves immunity to a particular disease. Research Groups. Fundamental and translational research in the Department of Ophthalmology is conducted by two research groups located in Canthia.

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Studies of the coronary circulation in Chagas’ heart disease.

Electrocardiographic abnormalities and left ventricular function in Chagas’ heart disease. Production of lesions in rabbits similar to those of chronic Chagas’ Disease in man.

Correlation between Trypanosoma cruzi parasitism and myocardial inflammatory infiltrate in human chronic chagas’ic myocarditis: Prevention strategies of cardioembolic ischemic stroke in Chagas’ disease. Em pacientes com IC descompensada, o uso de furosemida, em doses convencionais, melhora a sintomatologia Emerging acute Chagas disease in Amazonian Brazil: Amiodarone Trials Meta-analysis Investigators.

Benznidazol as a prophylactic drug to prevent reactivation in chronic chagasic patients treated with corticoid for associated diseases. A circulating IgG in Chagas’ disease wich binds to b-adrenoreceptors of myocardium and modulates their activity.

Simultaneous epicardial and endocardial substrate mapping and radiofrequency catheter ablation as first-line treatment for ventricular tachycardia and frequent ICD shocks in chronic chagasic cardiomyopathy. Recovery from heart norepinephrine depletion in experimental Chagas’ disease. A randomized, placebo-controlled trial assessing the effects of rosiglitazone on echocardiographic function and cardiac status in type 2 diabetic patients with New York Heart Association Functional Class I or II Heart Failure.


Combination of isosorbide dinitrate and hydralazine in blacks with heart failure. End-stage cardiomyopathy and secondary mitral insufficiency surgical alternative with prosthesis implant and left ventricular restoration.

Early occurrence of anti-muscarinic autoantibodies and abnormal vagal modulation in Chagas’ disease. II Heart transplantation in children. Rev Bras Cir Cardiovasc.

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Current expectations in dynamic cardiomyoplasty. J Am Coll Cardiol. Ministerio de La Salud de Chile. Doppler tissue imaging to assess systolic function in Chagas chagazica. Chagasic cardiopathy in endemic area versus sporadically infected patients. Removal of antiacetylcholine receptor antibodies by protein-A immunoadsorption in myasthenia gravis. Multicenter randomized trial of cell therapy in cardiopathies – MiHeart Study.

Research Groups

Cardiac morbity due to Chagas heart disease. Early results of bone marrow cell transplantation to the myocardium of patients with heart failure due to Chagas’ disease. J Heart Lung Transplant.

A century after Chagas disease discovery, hurdles to tackling the infection remain. Uber das neurotoxin des trypanosoma cruzi.

Role of autoantibodies in the physiopathology of chagas’ disease

Sera from chronic chagas’ic patients depress cardiac electrogenesis and conduction. Sera from chronic Chagas’ic patients with complex cardiac arrhythmias depress electrogenesis and conduction in isolated rabbit hearts. Bone marrow cell transplantation to the myocardium of a patient with heart failure due to Chagas’ disease. Luquetti AO, Rassi A. Antibodies to ribosomal P proteins of Trypanosoma cruzi in Chagas’ disease possess functional autoreactivity with heart tissue and differ from anti-P ribosomal autoantibodies in lupus.


Erythema nodoso in reactivation of Chagas’ disease after cardiac transplantation. Cutaneous manifestation of Chagas’ disease after heart transplantation: Magnetic resonance imaging evaluation of chronic changes in latissimus dorsi cardiomyoplasty. fisiopatllogia

Transmission of Trypanosoma cruzi by heart transplantation. Treatment of fisiopayologia rejection with methotrexate in stable patients submitted to heart transplantation.

Conduction defects and arrythmias in Chagas’ Disease: Chagas’ heart disease and Chagas’ syndromes: Cardiomyoplasty for treatment of heart failure. The challenge of chagas’ic cardiomyopathy. Sudden death in Chagas” disease.

Bone marrow cell transplantation to the myocardium of a patient with heart failure due to Chagas” disease. Treatment with benznidazole during the chronic phase of experimental Chagas’ disease decreases cardiac alterations.