BRINTELLIX safely and effectively. See full prescribing information for BRINTELLIX. BRINTELLIX (vortioxetine) tablets, for oral use. Initial U.S. Approval: Brintellix is not recommended for the treatment of depression in patients aged less than 18 years since the safety and efficacy of vortioxetine have not been. Product details on treatment with TRINTELLIX (vortioxetine), including available savings if eligible, and support sign-up. Watch videos of actual patients. See full.
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Steady-state plasma concentrations brintelljx typically reached within two weeks. The combination of vortioxetine with a reversible and selective MAO-A inhibitor, such as moclobemide, is contraindicated see section 4.
TGA eBS – Product and Consumer Medicine Information
If you take the wrong dose, Brintellix may not work as well and your condition may not improve. If your country is not on the listplease refer to our global contacts. In many cases, hyponatremia brintelkix to be the result of the syndrome of inappropriate antidiuretic hormone secretion SIADH. Occasionally, the symptoms of depression may include thoughts of suicide or self-harm.
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The reactions were usually transient and did not generally lead to cessation of therapy. The structural formula is:.
Vortioxetine – Wikipedia
The authors suggest that vortioxetine is currently a good second-line antidepressant option and shows promise, pending additional long-term data, to become a first-line antidepressant option. Healthcare professionals are asked to report any suspected adverse reactions via the national reporting system:. The risk differences drug vs.
If you are not sure what to do, ask your doctor or pharmacist. Vortioxetine did not separate from placebo on subjective measures when evaluated using the Cognitive and Physical Functioning Questionnaire with results of Tell your doctor if you are receiving electroconvulsive therapy. Hepatic impairment Vortioxetine has not been studied in patients with severe hepatic impairment and caution should be exercised when treating these patients see section 5. Vortioxetine had no effect relative to placebo on body weight, heart rate, or blood pressure in clinical short- and long-term studies.
Elderly patients may be at greater risk of developing hyponatremia with a serotonergic antidepressant. Brintellix 10 mg film-coated tablets Yellow, almond-shaped 5 x 8.
Case reports and epidemiological studies case-control and cohort design have demonstrated an association between use of drugs that interfere with serotonin reuptake and the occurrence of gastrointestinal bleeding. There is no clinical experience with concurrent administration of vortioxetine and ECT, therefore caution is advisable.
While you are taking Brintellix Things you must do Tell your doctor immediately if you become pregnant while taking Brintellix. These medicines may be affected by Brintellix, or may affect how well it works. Any unused medicinal product or waste material should be disposed of in accordance with local requirements. Brintellix 5 mg film-coated tablets Each film-coated tablet contains vortioxetine hydrobromide equivalent to 5 mg vortioxetine.
However, there is substantial evidence from placebo-controlled maintenance studies in adults with depression that the use of antidepressants can delay the recurrence of depression.
Absorption Vortioxetine is slowly, but well absorbed after oral administration and the peak plasma concentration is reached within 7 to 11 hours. Skin and subcutaneous tissue disorders. The ASEX scale includes five questions that pertain to the following aspects of sexual function: The companies agreed to co-promote the drug in the US and Japan, and that Lundbeck would receive a royalty on all such sales.
The information in this monograph is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects.
In clinical studies in children and adolescents treated with other antidepressants, suicide-related behaviour suicide attempt and suicidal thoughts and hostility predominantly aggression, oppositional behaviour, anger were more frequently observed than in bruntellix treated with placebo. Brintellix is a registered trade mark of H. Your doctor can discuss with you the risks and benefits involved.
Irreversible, selective MAO-B inhibitor selegiline, rasagiline Although a lower risk of serotonin syndrome is expected with selective MAO-B inhibitors than with MAO-A inhibitors, the combination of vortioxetine with irreversible MAO-B inhibitors, such as selegiline or rasagiline should be administered with caution.
However, prior to initiating treatment with an antidepressant, patients with depressive symptoms should be adequately screened to determine if they are at risk for bipolar disorder; such screening should include a detailed psychiatric history, including a family history of suicide, bipolar disorder, and depression. Negligible amounts of unchanged vortioxetine were excreted in the urine up to 48 hours.
Vortioxetinesold under the trade names Trintellix and Brintellixis an antidepressant medication that is used to treat depression.