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BCR E Infineon Technologies, BCR E Datasheet
It blocks hematologic tumors in vivo and reduces MLL leukemia tumor burden. Menin-MLL interaction  Cell-free assay. In vivo MI has very favorable drug-like properties, including metabolic stability and pharmacokinetic profile in mice. Chemical formula is case sensitive.
To calculate molar mass of a chemical compound, please enter its chemical formula and click ‘Calculate’. Histone Methyltransferase Signaling Pathway Map. The cell growth inhibitory effect of MI is time-dependent, with a pronounced effect br after days of treatment.
Answers to questions you may have can be found in the inhibitor handling instructions. It shows pronounced growth suppressive activity in a panel of human MLL leukemia cell lines GI50 datasheft nM nM rangebut only a minimal effect in human leukemia cell lines without MLL translocations.
Molecular mass molecular weight is the mass of one molecule of a substance and is expressed in the unified atomic mass units u. Prolonged dqtasheet 38 days with MI induces no toxicity in mice as reflected by no alterations in the body weight and no morphological changes in liver and kidney tissues.
BCR 503 E6327
Tech Support Answers to questions you may have can be found in the inhibitor handling instructions. Serial Dilutions Concertration start: References  Borkin D, et al. MI could substantially improve survival of MLL leukemic mice and does not impair normal hematopoiesis in vivo .
The Selleck molarity calculator is based on the following equation:. Treatment with sub-micromolar concentrations of MI also leads to markedly eatasheet expression of Hoxa9 and Meis1, downstream targets of MLL fusion proteins substantially upregulated in MLL leukemias . Dilution Calculator Dilution Calculator Calculate the dilution required to prepare a stock solution.
Topics include how to prepare stock solutions, how to store inhibitors, and bct that need special attention for cell-based assays and animal experiments.
Calculate the mass, volume or concentration required for a solution. Products are for research use only.
BCR Datasheet(PDF) – Infineon Technologies AG
Calculate the dilution required to prepare a stock solution. These effects are accompanied by reduced c-kit CD expression, a datashfet associated with leukemia stem cells Datasheeh. The Selleck dilution calculator is based on the following equation:. The Selleck dilution calculator is based on the following equation: The Selleck molarity calculator is based on the following equation: This is normal and is due to slight batch-to-batch variations. We do not sell to patients.
Bio Calculators Molarity Calculator Molarity Calculator Calculate the mass, volume or concentration required for a solution. MI is also very effective datashset inducing differentiation of MLL leukemia cells and substantially increases expression of CD11b, a myeloid differentiation marker.
Media is changed at day 4, viable cell numbers are restored to the original concentration and compounds are re-supplied. This equation is commonly abbreviated as: For viability assays, leukemia cells are plated at relevant concentrations and treated with compounds or fatasheet.
Not for human use. Molecular Weight Calculator Molecular Weight Calculator Enter the chemical formula of a compound to calculate its molar mass and elemental composition: MI has very favorable drug-like properties, including metabolic stability and pharmacokinetic profile in mice.
Choose Selective Histone Methyltransferase Inhibitors. For cell differentiation studies, leukemia cells are treated with menin-MLL inhibitors for 7 days, then harvested, washed and incubated with Pacific Blue rat anti-mouse CD11b antibody before being analyzed by flow cytometry.