Amikacina, sulfato de. Aminofilina/teofilina. Aminopentamida, sulfato hidro- genado de. Amiodarona, clorhidrato de. Amitriptilina, clorhidrato de. Amlodipina . AMICAR. Ácido aminocaproico. AMIKIN. Amikacina. AMITIZA. Lubiprostona. AMOXIL. Amoxicilina. AMPHOGEL. Hidróxido de aluminio. ANADROL. Oximetolona. 2) GENTAMICINA 3) AMIKACINA 4) NETILMIOCINA i>INH. DE LA SINTESIS DE FOLATOS: TRIMETROPRIM−SULFAMETOXAZOL i>VANCOMICINA i>.

Author: Brakus Zulura
Country: Japan
Language: English (Spanish)
Genre: Medical
Published (Last): 11 May 2016
Pages: 277
PDF File Size: 7.14 Mb
ePub File Size: 11.50 Mb
ISBN: 529-6-43709-908-7
Downloads: 68562
Price: Free* [*Free Regsitration Required]
Uploader: Zuzshura

Nephrotoxicity of gentamicin in neonates It is a well-established fact that gentamicin is a nephrotoxic agent and that this applies to neonates.

Serum concentrations of gentamicin must be monitored when treatment extends for more than 48 hours. Renal toxicity of aminoglycosides in the neonatal period. Gentamicin is faemacologia aminoglycoside antibiotic active against gram-negative aerobic bacillary infections.

Gentamicin is ototoxic and nephrotoxic. Brainstem-evoked potentials were normal in 15 of 16 children before treatment and in 14 of 16 children after treatment.

Gentamicin is an important antibiotic for the treatment of many serious gram-negative aerobic bacillary infections. Hypothermia, extracorporeal membrane oxygenation and the patent ductus arteriosus prolong the half-life of gentamicin.

Secretaria de Estado da Saúde – BVS

To reduce toxicity the trough concentration must be low and therefore one administration per day is the suggested regimen. They report that therapeutic doses of gentamicin result in urinary loss of sodium, calcium and magnesium in neonates immediately after the infusion of gentamicin and note that these electrolyte changes may be of clinical importance, especially for sick preterm neonates.


Le informazioni riportate non sono consigli medici e potrebbero non essere accurate. Oxford University Press is a department of the University of Oxford. Gatifloxacina se retiro del mercado en algunos paises. Auzerie, [Transplacental transfer of 5 antibiotics by in vitro human placental perfusion]. To purchase short term access, please sign in to your Oxford Academic account above.

Penicilina V via oral. Weight, urine output, gestational age, and postconceptional age had the highest correlation with the pharmacokinetic values.

amikacina by diego puga on Prezi

The kinetic parameters are highlighted in table 1. Amikaina applied gentamicin resulted in very low serum concentrations close to the minimal therapeutic levels and change in brainstem-evoked potentials suggest that there was no inpairement of auditory function occurred. The treatment of acute hematogenic osteomyelitis requires high concentrations of gentamicin administered locally for 3 weeks.

In patients still receiving extracorporeal oxygenation, the volume of distribution was larger, the clearance smaller and half-life longer compared to those removed from the procedure. Blood levels should always be measured in order to minimize this risk.

J Matern Fetal Neonatal Med.

No significant differences between both populations for gentamicin total body clearance were observed. This suggest no apparent drug adsorption onto the oxygenator membrane. Population pharmacokinetics of gentamicin in preterm neonates: At a postnatal age of 6 days half-life is longer than in infants with a postnatal age of 15 days.


Interindividual variability of aminoglycoside pharmacokinetics in preterm neonates at birth. Penicilina G Sodica o Potasica amikcaina. There were not differences among patients based on race.

Hawkey, Prospective study of the risk of Clostridium difficile diarrhoea in elderly patients following treatment with cefotaxime or piperacillin-tazobactam. The postnatal age is an important factor in determining the half-life and the clearance of gentamicin.

URL consultato il 9 febbraio Recently, a covariate model characterizing development changes in clearance of amikacin in neonates has been developed using birth weight and postnatal age. Patrizia Ciucci of the Medical Library of the University of Pisa for retrieving the scientific literature. Dajani, Pharmacokinetics of intravenously administered piperacillin in preadolescent children. Sign in via your Institution Sign in. Renal tubular damage is progressive with time and can even produce a Bartter-like syndrome.

High concentrations at least eight times the minimum inhibitory dose enhance the drug’s bactericidal effect. La trimetroprima se presenta ademas de como monodroga en combinacion fija con la sulfametoxazol, en una relacion 1: Il principio attivo trova utilizzo nel trattamento delle infezioni intra-addominali, ginecologiche, del tratto urinario e delle basse vie respiratorie.

A loading dose is useful to increase the peak concentration shortly after the administration.